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the sleep of dogs caused by a dose of twenty or thirty Zaditor Cost grains of chloral does Zaditor Price not continue much longer than two hours, unless the dose be repeated. Experiment XII. — A dog was put to sleep by twenty grains of chloral, and her exhalations conducted, as Zaditor Eye Drops in the pre- vious experiment, through the combustion-tube (porcelain) for fifteen minutes, and into a silver solution, without producing a precipitate. The dog was then allowed to take three inspira- tions of Order Zaditor air impregnated with chloroform, and the exhalations were conducted as before, in five minutes producing a dense white precipitate, insoluble in nitric acid, but soluble in am- monia. The sleep Buy Zaditor Online continued for two hours. ExPEEiMENT XIII. — Twenty-five grains of chloral were swallowed by a fasting dog. Generic Zaditor In a very few moments he went off into Zaditor Tablets a liglit slumber, which lasted five hours. His exhala- tions from Zaditor Coupon mouth and nostrils were conducted through a red- Buy Zaditor hot tube into a j)otassa-bulb, containing, as before, the acidu- Alaway Or Zaditor lated aqueous solution of nitrate of silver. Purchase Zaditor The exhalations were thus consumed in the tube for one hour and twenty min- utes, at the end of which time the silver solution was free from any precipitate, and perfectly clear. The dog was re- moved from the muzzle, and then half a dozen inspirations of chloroform were administered, and his exhalations consumed as before. The silver solution became immediately turbid, the smell of chlorine was very marked, and a dense white pre- cipitate was deposited in the silver solution, which was Zaditor Eye Drop insol- uble in nitric acid, and soluble in ammonia. A portion of the liquid containing the silver solution was boiled, and oxide of silver was deposited at the bottom of the test-tube. ExPEEiMENT XI Y. — A dog was made to swallow forty grains of chloral, and in fifteen minutes was sound asleep. His exhalations were conducted through the same apparatus as before Zaditor Drops described, and thus consumed for three-quarters of an hour, without interfering in the least with the clearness of the silver solution. At the end of this time, I introduced subcutaneously a few drops of chloroform diluted with water, in the outside of the thigh. In five to ten minutes after, a white precipitate appeared in the silver solution, which was i]jsoluble in nitric acid, but soluble in ammonia ; a portion of WITH CHLOEAL-HYDRATE. 621 the liquid containing the precipitate was boiled, and a me- tallic oxide of silver was deposited. The place where the injection was made became inflamed, and an nicer appeared, which was slow to heal. These experiments were repeated several times, but in- variably with the same result, viz. : That, unless chloroform was administered by inlialation or by subcutaneous injection, during the sleep caused by chloral, no chloroform is eliminated by the lungs. It remains to bs Eye Drops Zaditor seen whether chloroform is present in the urine of a person taking chloral. Comparison of Effects of Chloroform, of Chloral-hydrate, and of Morphia. — I do not desire, in this paper, to enter into the discussion with regard to the physiological action of chloroform, as I should not then be able to consider at suf- ficient length the action of chloral. I have, however, made several experiments upon the mode of action of chloroform as an anaesthetic agent, and, as these results have a special bear- ing upon the important question whether chloral acts by its slow decomposition in the tissue, I will relate the deductions that I have drawn from my series of experiments, which have never yet been published ; 1. The elective action of chloroform for the cerebro-spinal system, upheld by MM. Lallemand, Perrin, and Duroy, by Dr. Anstie, and by others, is not yet proved. Tlie experi- ments undertaken to disprove tliis theory, by Gosselin, by Snow, and by Richardson, seem to show that, if the brain of Purchase Zaditor Online an animal is moistened with chloroform, no anaesthesia follows. 2. The injection of chloroform into arteries or veins of any Zaditor Coupons portion of the body does not cause anaesthesia, unless a sufii- cient quantity is injected to produce coma or death ; the carotid, the femoral, and the brachial arteries, were employed in this method of Buy Cheap Zaditor experimentation. Ko sleep followed, unless coma and death supervened. It was observed that the chloroform was absorbed by the tissues, and eliminated by the lungs. 3. Blood was directly transfused from one dog, who was in a complete state of anaesthesia from the inhalation of chloroform, to another who had not inhaled Order Zaditor Online chloroform. Five minutes from the commencement of the transfusion, chloro- form was exhaled from the lungs of the second dog, though ti 622 EXPEEIMENTS ON ANniALS, ETC. could not be perceived before. The transfusion was continued without interruption for from fifteen to twenty minutes, beyond which time clots were formed in the Cheap Zaditor tube, so as to interfere with the continuation of the experiment. This experiment was re- peated several times with the same result. There was not the slightest appearance of abolition of pain, nor any attempt to sleep, on the part of the second dog. The transfusions were con-

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